Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
نویسندگان
چکیده
منابع مشابه
Confounding in Observational Studies Explained
Practical and ethical constraints mean that many clinical and/or epidemiological questions cannot be answered through the implementation of a randomized controlled trial. Under these circumstances, observational studies are often required to assess relationships between certain exposures and disease outcomes. Unfortunately, observational studies are notoriously vulnerable to the effect of diffe...
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ABSTRACT Background: The current practice to measure RV is either by BPG or helium dilution methods which may not be available in all clinics due to their cost. Methods: This paper outlines a method for both direct and indirect calculation of RV via PFT with acceptable sensitivity (81 %, 60% ), specificity (71 %, 94%) and validity (76%, 78%) for obstructive and restrictive lung disease respect...
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متن کاملImportance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia.
OBJECTIVES To document the effects of appropriate and inappropriate empirical antibiotic therapy on mortality in a cohort of patients with bacteraemia due to methicillin-resistant Staphylococcus aureus (MRSA) and to summarize effects with previous studies. METHODS In the retrospective cohort study, episodes of clinically significant MRSA bacteraemia during a 15 year period were included. Poly...
متن کاملComparison of mortality of patients with Acinetobacter baumannii bacteraemia receiving appropriate and inappropriate empirical therapy.
OBJECTIVES To evaluate the effect of inappropriate empirical antimicrobial treatment on the mortality of patients with Acinetobacter baumannii bacteraemia. METHODS Retrospective cohort study of patients with A. baumannii bacteraemia hospitalized at the Henry Dunant hospital from January 2002 to December 2004. RESULTS Among 40 patients with A. baumannii bacteraemia, 22 (55%) and 18 (45%) rec...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0225478